CLINICAL STUDIES AND RESEARCH REPORTS

I. Medical Research Reports on Kintopill™

Medical research reports on KINTOPILL (abstract)

Analysis of Weight-Reducing/ reduction? Effects of Kintopill™ in Obese Rats

(Chen Yu, et al. Department of Pathophysiology, Shanghai Medical
University, Shanghai, 200032)

Objective:   To investigate the weight-reducing effect of Kintopill™ and its probable mechanism in obese rats.

Method:   The obese rats' body weight, Lee's index, total weight of celiac fat tissue, adipocyte size, blood glucose, blood lipid, expression of leptin in adipocyte (ABC method), level of surem leptin (RIA) were chosen as the indexes.

Results:  After administration of Kintopill™ (40mg/100g B.W./d.), the rats lost their body weights to some extent. At the same time, blood cholesterol and glucose levels were lowered and adipocyte's leptin expression reduced, while serum leptin levels were elevated.

Conclusions:  Kintopill™ reduces the weight of obese rats when it is administered to the rats for more than thirty days with a dosage of 40 mg/100g B. W./d.

The mechanism of its weight-reducing effect may be related to serum leptin elevation. It also lowers blood cholesterol levels. As obesity is frequently accompanied by hyperglycemia, blood glucose can be reduced to lower levels when Kintopill™ is administrated.

 

An Experimental Study on the Preventing Obesity by Kintopill™ in Rats
(Qu Xiaoyi, et al. Department of Pathophysiology, Shanghai Medical University, Shanghai, 200032)

Objective:   To investigate the effects of Kintopill™ in preventing obesity and its probable mechanism in obese rats.

Method:   Twenty-six newborn SD rats were randomly grouped as prevention group (n=8), control group (n=8) and normal group (n=10).  The rats in the prevention group and control group were fed with high-energy forage and those in the normal group were fed with ordinary forage. The rats in prevention group were administrated with Kintopill™ (40mg/100g B.W./d.) from 9th to 17th weeks.

Dynamic changes in body weight, celiac fat weight and adipocytes were measured. Immunnohistological analysis of leptin in celiac adipocytes (ABC method) and the measurement of serum leptin levals (RIA method) were conducted.

Results:  The body weight and net weight of celiac fat were  lower, their adipocytes were smaller and immunochemical stainings of leptin were weaker in the prevention group than that in the control group. There was an obvious positive relationship between the expression of leptin and celiac fat tissue weight
(r=0.8663, P<0.05). But the changes in serum leptin levels were not significant.

Conclusion:  Kintopill™ (40mg/100g B.W./d.) can prevent obesity in rats fed with high-enegy forage. The mechanism may be related to the decrease of adipocytes leptin expression.

 

 


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